The most impressive clinical feature of acute promyelocytic leukemia (APL) at diagnosis is the presence in 80% to 90% of patients of a severe hemorrhagic syndrome. Recent data favor a fibrinolytic/proteolytic process rather than a disseminated intravascular coagulation as the mechanism mainly responsible for the hemorrhagic diathesis in APL. Morphologically, two main cytologic variants have been Identified: the classical hypergranular APL (M3), which represents the great majority of all APL, and the microgranular variant (M3v), which accounts for about 15% to 20% of all APL. A rare basophilic variant has also been described. With regard to prognosis, it has markedly changed from that of a rapidly fatal acute leukemia to that of a highly curable disease. This revolutionary progress was mainly due to the introduction during the 1990s of all-trans retinoic acid (ATRA) for the treatment of this disease. After the introduction of ATRA, in addition to clinical features such as hyperleukocytosis (white blood cell count > 10 x 10(9)/L) or thrombocytopenia (platelet count < 10 x 10(3)/L) at presentation, immunophenotype markers and polymerase chain reaction status for promyelocytic leukemia/retinoic acid receptor-alpha during follow-up also had an impact on prognosis.
Avvisati, G., Lo Coco, F., & Mandelli, F. (2001). Acute promyelocytic leukemia: clinical and morphologic features and prognostic factors. SEMINARS IN HEMATOLOGY, 38(1), 4-12.
|Tipologia:||Articolo su rivista|
|Citazione:||Avvisati, G., Lo Coco, F., & Mandelli, F. (2001). Acute promyelocytic leukemia: clinical and morphologic features and prognostic factors. SEMINARS IN HEMATOLOGY, 38(1), 4-12.|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Revisione (peer review):||Esperti anonimi|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||gen-2001|
|Titolo:||Acute promyelocytic leukemia: clinical and morphologic features and prognostic factors|
|Autori:||Avvisati, G; Lo Coco, F; Mandelli, F|
|Appare nelle tipologie:||01 - Articolo su rivista|