Body mass index and acid phosphatase locus 1 in diabetic disorders

The polymorphic enzyme acid phosphatase locus 1 (ACP1) is a candidate gene for obesity disorders. The enzyme is able to dephosphorylate the insulin receptor. Our group has observed a lower plasma glucose level in diabetic subjects carrying the low activity ACP1 phenotypes A and BA, and a positive association between these genotypes and body mass index (BMI). We have now analysed the relationship between BMI and ACP1 in gestational diabetes and in women with type 1 diabetes. We have studied 106 Caucasian women with type 1 diabetes who had previously delivered a liveborn infant, 99 Caucasian women who had had gestational diabetes and 387 healthy fertile women from the same population as controls. ACP1 phenotype was determined by starch gel electrophoresis. In overweight women (BMI > 25), the proportion of low activity ACP1 phenotypes is much lower in type 1 diabetes than in gestational diabetes and in healthy females. In women with BMI ≤ 25, the proportion of low activity ACP1 phenotypes is slightly lower in gestational diabetes than in type 1 diabetes. Low activity ACP1 phenotypes have diverse effects on susceptibility to overweight depending on the class of diabetic disorder: in subjects with type 2 diabetes and in subjects with gestational diabetes low activity ACP1 phenotypes predispose to an increase in BMI, while in type 1 diabetes these ACP1 phenotypes seem to protect from overweight.