The successful use of differentiating treatment for patients with acute promyelocytic leukemia (APL) suggests that other acute myeloid leukemias (AML) may benefit from tailored and subtype-specific therapy. Despite the fact that new drugs specifically targeting AML genetic lesions have not yet been developed, distinct karyotypic categories have been identified which may deserve differentiated treatment. In addition, molecular assays to assess response to therapy more sensitively are now available for several AML subsets. In this review, we discuss the role of genetic characterization in the therapy of AML, and the investigative efforts which we believe are still needed for the design of tailored treatment for each and every patient with this disease.
Mandelli, F., Petti, M.c., & Lo Coco, F. (1998). Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach. HAEMATOLOGICA, 83(11), 1015-1023.
Tipologia: | Articolo su rivista | |
Citazione: | Mandelli, F., Petti, M.c., & Lo Coco, F. (1998). Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach. HAEMATOLOGICA, 83(11), 1015-1023. | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | nov-1998 | |
Titolo: | Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach | |
Autori: | ||
Autori: | Mandelli, F; Petti, Mc; Lo Coco, F | |
Appare nelle tipologie: | 01 - Articolo su rivista |