The successful use of differentiating treatment for patients with acute promyelocytic leukemia (APL) suggests that other acute myeloid leukemias (AML) may benefit from tailored and subtype-specific therapy. Despite the fact that new drugs specifically targeting AML genetic lesions have not yet been developed, distinct karyotypic categories have been identified which may deserve differentiated treatment. In addition, molecular assays to assess response to therapy more sensitively are now available for several AML subsets. In this review, we discuss the role of genetic characterization in the therapy of AML, and the investigative efforts which we believe are still needed for the design of tailored treatment for each and every patient with this disease.

Mandelli, F., Petti, M., LO COCO, F. (1998). Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach. HAEMATOLOGICA, 83(11), 1015-1023.

Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach

LO COCO, FRANCESCO
1998-11-01

Abstract

The successful use of differentiating treatment for patients with acute promyelocytic leukemia (APL) suggests that other acute myeloid leukemias (AML) may benefit from tailored and subtype-specific therapy. Despite the fact that new drugs specifically targeting AML genetic lesions have not yet been developed, distinct karyotypic categories have been identified which may deserve differentiated treatment. In addition, molecular assays to assess response to therapy more sensitively are now available for several AML subsets. In this review, we discuss the role of genetic characterization in the therapy of AML, and the investigative efforts which we believe are still needed for the design of tailored treatment for each and every patient with this disease.
nov-1998
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow Transplantation; Chromosome Aberrations; DNA-Binding Proteins; Feasibility Studies; Humans; Karyotyping; Leukemia, Myeloid; Palliative Care; Prognosis; Remission Induction; Risk; Salvage Therapy; Transcription Factors; Treatment Outcome; Case Management; Neoplasm Proteins
Mandelli, F., Petti, M., LO COCO, F. (1998). Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach. HAEMATOLOGICA, 83(11), 1015-1023.
Mandelli, F; Petti, M; LO COCO, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161810
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 31
social impact