Retinoids, which are derivatives of vitamin A, induce differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients. However, APL cells develop resistance to retinoic acid treatment. Arsenic trioxide (As2O3) can induce clinical remission in patients with APL, including those who have relapsed after retinoic acid treatment, by inducing apoptosis (programmed cell death) of the leukemia cells. In this study, we investigated the molecular mechanisms by which As2O3 induces apoptosis in retinoic acid-sensitive NB4 APL cells, in retinoic acid-resistant derivatives of these cells, and in fresh leukemia cells from patients.

Shao, W., Fanelli, M., Ferrara, F.f., Riccioni, R., Rosenauer, A., Davison, K., et al. (1998). Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 90(2), 124-133.

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

LO COCO, FRANCESCO;
1998

Abstract

Retinoids, which are derivatives of vitamin A, induce differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients. However, APL cells develop resistance to retinoic acid treatment. Arsenic trioxide (As2O3) can induce clinical remission in patients with APL, including those who have relapsed after retinoic acid treatment, by inducing apoptosis (programmed cell death) of the leukemia cells. In this study, we investigated the molecular mechanisms by which As2O3 induces apoptosis in retinoic acid-sensitive NB4 APL cells, in retinoic acid-resistant derivatives of these cells, and in fresh leukemia cells from patients.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - Malattie del Sangue
English
Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenicals; Blotting, Northern; Blotting, Western; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Leukemia, Promyelocytic, Acute; Oxides; Receptors, Retinoic Acid; Transglutaminases; Tretinoin; Tumor Cells, Cultured
Shao, W., Fanelli, M., Ferrara, F.f., Riccioni, R., Rosenauer, A., Davison, K., et al. (1998). Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 90(2), 124-133.
Shao, W; Fanelli, M; Ferrara, F; Riccioni, R; Rosenauer, A; Davison, K; Lamph, W; Waxman, S; Pelicci, P; LO COCO, F; Avvisati, G; Testa, U; Peschle, C; Gambacorti Passerini, C; Nervi, C; Miller, W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161738
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