About 40 percent of non-Hodgkin's lymphomas are diffuse lymphomas with a large-cell component (DLLC). Current therapy can induce a long-term remission in half the patients with DLLC, but more intensive treatment has the potential to improve outcome, particularly in patients at high risk for treatment failure. Clinical and cytogenetic markers can identify subgroups at high or low risk. Rearrangement of a novel candidate proto-oncogene, bcl-6, is a possible prognostic indicator in DLLC.

Offit, K., LO COCO, F., Louie, D., Parsa, N., Leung, D., Portlock, C., et al. (1994). Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. THE NEW ENGLAND JOURNAL OF MEDICINE, 331(2), 74-80 [10.1056/NEJM199407143310202].

Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma

LO COCO, FRANCESCO;
1994-07-14

Abstract

About 40 percent of non-Hodgkin's lymphomas are diffuse lymphomas with a large-cell component (DLLC). Current therapy can induce a long-term remission in half the patients with DLLC, but more intensive treatment has the potential to improve outcome, particularly in patients at high risk for treatment failure. Clinical and cytogenetic markers can identify subgroups at high or low risk. Rearrangement of a novel candidate proto-oncogene, bcl-6, is a possible prognostic indicator in DLLC.
14-lug-1994
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Aged; Biomarkers, Tumor; Blotting, Southern; Confidence Intervals; DNA-Binding Proteins; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Regression Analysis; Transcription Factors; Gene Rearrangement
Offit, K., LO COCO, F., Louie, D., Parsa, N., Leung, D., Portlock, C., et al. (1994). Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. THE NEW ENGLAND JOURNAL OF MEDICINE, 331(2), 74-80 [10.1056/NEJM199407143310202].
Offit, K; LO COCO, F; Louie, D; Parsa, N; Leung, D; Portlock, C; Ye, B; Lista, F; Filippa, D; Rosenbaum, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161692
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