A rearrangement between the PML and RAR-alpha genes underlies the acute promyelocytic leukemia (APL)-specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-alpha hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.

Diverio, D., Pandolfi, P., Rossi, V., Biondi, A., Pelicci, P., LO COCO, F. (1994). Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR. LEUKEMIA, 8 Suppl 2, S63-s65.

Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR

LO COCO, FRANCESCO
1994-01-01

Abstract

A rearrangement between the PML and RAR-alpha genes underlies the acute promyelocytic leukemia (APL)-specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-alpha hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.
1994
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 17; Humans; Leukemia, Promyelocytic, Acute; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; RNA, Messenger; Translocation, Genetic; Treatment Outcome
Diverio, D., Pandolfi, P., Rossi, V., Biondi, A., Pelicci, P., LO COCO, F. (1994). Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR. LEUKEMIA, 8 Suppl 2, S63-s65.
Diverio, D; Pandolfi, P; Rossi, V; Biondi, A; Pelicci, P; LO COCO, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161635
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