The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.

Longo, L., Trecca, D., Biondi, A., LO COCO, F., Grignani, F., Maiolo, A., et al. (1993). Frequency of RAS and p53 mutations in acute promyelocytic leukemias. LEUKEMIA & LYMPHOMA, 11(5-6), 405-410 [10.3109/10428199309067933].

Frequency of RAS and p53 mutations in acute promyelocytic leukemias

LO COCO, FRANCESCO;
1993-01-01

Abstract

The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.
1993
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Base Sequence; Humans; Leukemia, Promyelocytic, Acute; Molecular Sequence Data; Genes, p53; Genes, ras; Mutation
Longo, L., Trecca, D., Biondi, A., LO COCO, F., Grignani, F., Maiolo, A., et al. (1993). Frequency of RAS and p53 mutations in acute promyelocytic leukemias. LEUKEMIA & LYMPHOMA, 11(5-6), 405-410 [10.3109/10428199309067933].
Longo, L; Trecca, D; Biondi, A; LO COCO, F; Grignani, F; Maiolo, A; Pelicci, P; Neri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161616
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