Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset.

Cimino, G., LO COCO, F., Biondi, A., Elia, L., Luciano, A., Croce, C., et al. (1993). ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. BLOOD, 82(2), 544-546.

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

LO COCO, FRANCESCO;
1993-07-15

Abstract

Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset.
15-lug-1993
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Acute Disease; DNA, Neoplasm; Deoxyribonuclease BamHI; Deoxyribonuclease HindIII; Female; Gene Rearrangement; Humans; Infant; Karyotyping; Leukemia; Male; Restriction Mapping; Chromosome Aberrations; Chromosomes, Human, Pair 11
Cimino, G., LO COCO, F., Biondi, A., Elia, L., Luciano, A., Croce, C., et al. (1993). ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. BLOOD, 82(2), 544-546.
Cimino, G; LO COCO, F; Biondi, A; Elia, L; Luciano, A; Croce, C; Masera, G; Mandelli, F; Canaani, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/161611
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