The pathogenesis of several subtypes of non-Hodgkin's lymphoma (NHL) is associated with specific genetic lesions involving oncogenes and tumor-suppressor genes. These lesions include c-myc translocation and p53 inactivation in small noncleaved-cell lymphoma, and bcl-2 and bcl-1 translocation in follicular (FL) and mantle-zone lymphoma, respectively. Relatively little is known, however, about the pathogenesis of diffuse lymphoma with a large-cell component (DLLC; including large-, mixed-cell, and immunoblastic), the most relevant NHL type in terms of morbidity and mortality. Since DLLC can occur 'de novo' or via histologic transformation of follicular lymphoma, it is critical to identify lesions associated with both pathogenetic pathways.

Dalla-Favera, R., Ye, B.h., Lo Coco, F., Gaidano, G., Lista, F., Knowles, D.m., et al. (1994). Identification of genetic lesions associated with diffuse large-cell lymphoma. ANNALS OF ONCOLOGY, 5 Suppl 1, 55-60.

Identification of genetic lesions associated with diffuse large-cell lymphoma

LO COCO, FRANCESCO;
1994

Abstract

The pathogenesis of several subtypes of non-Hodgkin's lymphoma (NHL) is associated with specific genetic lesions involving oncogenes and tumor-suppressor genes. These lesions include c-myc translocation and p53 inactivation in small noncleaved-cell lymphoma, and bcl-2 and bcl-1 translocation in follicular (FL) and mantle-zone lymphoma, respectively. Relatively little is known, however, about the pathogenesis of diffuse lymphoma with a large-cell component (DLLC; including large-, mixed-cell, and immunoblastic), the most relevant NHL type in terms of morbidity and mortality. Since DLLC can occur 'de novo' or via histologic transformation of follicular lymphoma, it is critical to identify lesions associated with both pathogenetic pathways.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - Malattie del Sangue
English
Humans; Lymphoma, Large B-Cell, Diffuse; Mutation; Proto-Oncogenes; Transformation, Genetic; Translocation, Genetic
Dalla-Favera, R., Ye, B.h., Lo Coco, F., Gaidano, G., Lista, F., Knowles, D.m., et al. (1994). Identification of genetic lesions associated with diffuse large-cell lymphoma. ANNALS OF ONCOLOGY, 5 Suppl 1, 55-60.
Dalla Favera, R; Ye, B; LO COCO, F; Gaidano, G; Lista, F; Knowles, D; Louie, D; Offit, K; Chaganti, R
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/161556
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact