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EnglishRepeated PCR analysis was performed on bone marrow and/or peripheral blood samples from 4 CML patients in complete cytogenetic remission during treatment with IFN-alpha. Two patients became PCR-negative. One was negative for the analyses carried out from the 9th to the 30th months, but reverted to PCR positivity 10 months after IFN was reduced from 1.5 x 10(6) IU/day to 1 x 10(6) IU and given on alternate days. Although the dose was again raised to 3 x 10(6) IU/day, 8 months later her peripheral blood cells were still PCR-positive, but remained persistently Ph'-negative. Another patient became PCR-negative at the 42nd month and remained so at the last analysis performed 3 months later. Two patients were persistently PCR-positive. Cytogenetic relapse was documented in both, in one while still on full therapy. Ph'-positive metaphases reappeared in the other patient 7 months after discontinuing IFN-alpha therapy.
Liberati, A.m., Donti, E., Rosso, C., Lo Coco, F., Dore, F., Pardini, S., et al. (1994). Repeated PCR in CML during IFN-alpha therapy. EUROPEAN JOURNAL OF HAEMATOLOGY, 52(3), 152-155.
| Tipologia: | Articolo su rivista | |
| Citazione: | Liberati, A.m., Donti, E., Rosso, C., Lo Coco, F., Dore, F., Pardini, S., et al. (1994). Repeated PCR in CML during IFN-alpha therapy. EUROPEAN JOURNAL OF HAEMATOLOGY, 52(3), 152-155. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | mar-1994 | |
| Titolo: | Repeated PCR in CML during IFN-alpha therapy | |
| Autori: | ||
| Autori: | Liberati, Am; Donti, E; Rosso, C; Lo Coco, F; Dore, F; Pardini, S; Cocco, S; Addis, M; Saglio, G | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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