We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.

LO COCO, F., Francia di Celle, P., Alimena, G., De Rossi, G., Gastaldi, R., Casorati, G., et al. (1989). Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features. LEUKEMIA, 3(1), 79-82.

Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features

LO COCO, FRANCESCO;
1989-01-01

Abstract

We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
gen-1989
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Adult; Chromosome Aberrations; Chromosome Disorders; Female; Gene Rearrangement, T-Lymphocyte; Humans; Karyotyping; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes; Chromosomes, Human, Pair 4; Translocation, Genetic
LO COCO, F., Francia di Celle, P., Alimena, G., De Rossi, G., Gastaldi, R., Casorati, G., et al. (1989). Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features. LEUKEMIA, 3(1), 79-82.
LO COCO, F; Francia di Celle, P; Alimena, G; De Rossi, G; Gastaldi, R; Casorati, G; Saglio, G; Foa, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/160982
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