We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
Lo Coco, F., Francia di Celle, P., Alimena, G., De Rossi, G., Gastaldi, R., Casorati, G., et al. (1989). Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features. LEUKEMIA, 3(1), 79-82.
Tipologia: | Articolo su rivista | |
Citazione: | Lo Coco, F., Francia di Celle, P., Alimena, G., De Rossi, G., Gastaldi, R., Casorati, G., et al. (1989). Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features. LEUKEMIA, 3(1), 79-82. | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | gen-1989 | |
Titolo: | Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features | |
Autori: | ||
Autori: | Lo Coco, F; Francia di Celle, P; Alimena, G; De Rossi, G; Gastaldi, R; Casorati, G; Saglio, G; Foa, R | |
Appare nelle tipologie: | 01 - Articolo su rivista |