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EnglishDespite the impressive results obtained with standard chemotherapy, approximately 20% of acute promyelocytic leukemia (APL) patients undergo disease relapse thereby requiring salvage therapy. Few data is available on long-term prognosis in relation to time to complete remission (CR): we reviewed 142 patients treated with AIDA protocols and we found that 42 out of 142 (29.6%) patients achieved CR after 35 days (median time, 42 days). No significant differences in presenting features, including FAB subtype, type of PML/RARA transcript and relapse risk at presentation between the two patient groups achieving CR > or <35 days were revealed, except for male sex and older age that were significantly associated with delayed CR. Rate of relapse was 31% in patients with delayed CR compared to 17% in the group of patients who achieved CR<35 days (p=0.001), with a 5-year CIR of 29.6% compared to 12% (p=0.03). APL patients with delayed CR should be more closely monitored during follow-up for early identification of relapse and prompt administration of pre-emptive salvage therapy.
Breccia, M., Minotti, C., Latagliata, R., Loglisci, G., Salaroli, A., Loglisci, M.g., et al. (2013). Influence of time to complete remission and duration of all-trans retinoic acid therapy on the relapse risk in patients with acute promyelocytic leukemia receiving AIDA protocols. LEUKEMIA RESEARCH, 37(4), 383-385 [10.1016/j.leukres.2012.11.014].
| Tipologia: | Articolo su rivista | |
| Citazione: | Breccia, M., Minotti, C., Latagliata, R., Loglisci, G., Salaroli, A., Loglisci, M.g., et al. (2013). Influence of time to complete remission and duration of all-trans retinoic acid therapy on the relapse risk in patients with acute promyelocytic leukemia receiving AIDA protocols. LEUKEMIA RESEARCH, 37(4), 383-385 [10.1016/j.leukres.2012.11.014]. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.leukres.2012.11.014 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2013 | |
| Titolo: | Influence of time to complete remission and duration of all-trans retinoic acid therapy on the relapse risk in patients with acute promyelocytic leukemia receiving AIDA protocols | |
| Autori: | ||
| Autori: | Breccia, M; Minotti, C; Latagliata, R; Loglisci, G; Salaroli, A; Loglisci, Mg; Lo Coco, F | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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