The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity and phagocytosis. In human, the function and biological significance of TM9SF4 are currently under investigation. However, TM9SF4 was found overexpressed in human metastatic melanoma and in a small subset of acute myeloid leukemia (AMLs) and myelodysplastic syndromes, consistent with an oncogenic function of this gene.

Paolillo, R., Spinello, I., Quaranta, M., Pasquini, L., Pelosi, E., LO COCO, F., et al. (2015). Human TM9SF4 is a new gene down-regulated by hypoxia and involved in cell adhesion of leukemic cells. PLOS ONE, 10(5), e0126968 [10.1371/journal.pone.0126968].

Human TM9SF4 is a new gene down-regulated by hypoxia and involved in cell adhesion of leukemic cells

PASQUINI, LUCA;LO COCO, FRANCESCO;
2015-01-01

Abstract

The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity and phagocytosis. In human, the function and biological significance of TM9SF4 are currently under investigation. However, TM9SF4 was found overexpressed in human metastatic melanoma and in a small subset of acute myeloid leukemia (AMLs) and myelodysplastic syndromes, consistent with an oncogenic function of this gene.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Apoptosis; Bone Marrow Cells; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cloning, Molecular; Fibronectins; Granulocytes; HEK293 Cells; Hematopoietic Stem Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Membrane Proteins; Monocytes; Neoplasm Proteins; Oxygen; Primary Cell Culture; Promoter Regions, Genetic; Signal Transduction; Tumor Cells, Cultured; Gene Expression Regulation, Leukemic
Paolillo, R., Spinello, I., Quaranta, M., Pasquini, L., Pelosi, E., LO COCO, F., et al. (2015). Human TM9SF4 is a new gene down-regulated by hypoxia and involved in cell adhesion of leukemic cells. PLOS ONE, 10(5), e0126968 [10.1371/journal.pone.0126968].
Paolillo, R; Spinello, I; Quaranta, M; Pasquini, L; Pelosi, E; LO COCO, F; Testa, U; Labbaye, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/160477
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