Recent studies indicate that angiogenesis is important in the pathogenesis of acute myeloid leukemias (AMLs). Among the various AMLs, the bone marrow angiogenetic response is particularly pronounced in acute promyelocytic leukemia (APL). However, the molecular mechanisms responsible for this angiogenetic response are largely unknown. In the present study, we have explored the role of HHEX, a homeodomain transcription factor, as a possible mediator of the pro-angiogenetic response observed in APL. This transcription factor seems to represent an ideal candidate for this biologic function because it is targeted by PML-RARα, is capable of interaction with PML and PML-RARα, and acts as a regulator of the angiogenetic response.
Saulle, E., Petronelli, A., Pelosi, E., Coppotelli, E., Pasquini, L., Ilari, R., et al. (2016). PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response. JOURNAL OF HEMATOLOGY & ONCOLOGY, 9(1), 33 [10.1186/s13045-016-0262-5].
Tipologia: | Articolo su rivista | |
Citazione: | Saulle, E., Petronelli, A., Pelosi, E., Coppotelli, E., Pasquini, L., Ilari, R., et al. (2016). PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response. JOURNAL OF HEMATOLOGY & ONCOLOGY, 9(1), 33 [10.1186/s13045-016-0262-5]. | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/s13045-016-0262-5 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 7-apr-2016 | |
Titolo: | PML-RAR alpha induces the downmodulation of HHEX: A key event responsible for the induction of an angiogenetic response | |
Autori: | ||
Autori: | Saulle, E; Petronelli, A; Pelosi, E; Coppotelli, E; Pasquini, L; Ilari, R; Lo Coco, F; Testa, U | |
Appare nelle tipologie: | 01 - Articolo su rivista |