The initial results of the APL0406 trial showed that the combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) is at least not inferior to standard ATRA and chemotherapy (CHT) in first-line therapy of low- or intermediate-risk acute promyelocytic leukemia (APL). We herein report the final analysis on the complete series of patients enrolled onto this trial.

Platzbecker, U., Avvisati, G., Cicconi, L., Thiede, C., Paoloni, F., Vignetti, M., et al. (2017). Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial. JOURNAL OF CLINICAL ONCOLOGY, 35(6), 605-612 [10.1200/JCO.2016.67.1982].

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial

AMADORI, SERGIO;LO COCO, FRANCESCO
2017-01-01

Abstract

The initial results of the APL0406 trial showed that the combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) is at least not inferior to standard ATRA and chemotherapy (CHT) in first-line therapy of low- or intermediate-risk acute promyelocytic leukemia (APL). We herein report the final analysis on the complete series of patients enrolled onto this trial.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Platzbecker, U., Avvisati, G., Cicconi, L., Thiede, C., Paoloni, F., Vignetti, M., et al. (2017). Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial. JOURNAL OF CLINICAL ONCOLOGY, 35(6), 605-612 [10.1200/JCO.2016.67.1982].
Platzbecker, U; Avvisati, G; Cicconi, L; Thiede, C; Paoloni, F; Vignetti, M; Ferrara, F; Divona, M; Albano, F; Efficace, F; Fazi, P; Sborgia, M; Di Bona, E; Breccia, M; Borlenghi, E; Cairoli, R; Rambaldi, A; Melillo, L; La Nasa, G; Fiedler, W; Brossart, P; Hertenstein, B; Salih, H; Wattad, M; Lübbert, M; Brandts, C; Hänel, M; Röllig, C; Schmitz, N; Link, H; Frairia, C; Pogliani, E; Fozza, C; D'Arco, A; Di Renzo, N; Cortelezzi, A; Fabbiano, F; Döhner, K; Ganser, A; Döhner, H; Amadori, S; Mandelli, F; Ehninger, G; Schlenk, R; LO COCO, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/160427
Citazioni
  • ???jsp.display-item.citation.pmc??? 118
  • Scopus 273
  • ???jsp.display-item.citation.isi??? 256
social impact