Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The inflammatory disorders associated to HTLV-1 are mediated by different proinflammatory cytokines as IL-1α, IL-6, TNF-α. The release and the role of IL-17 is still debated. Aims of this study were to analyze IL-17 induction by HTLV-1 infection and to determine whether resveratrol (RES) is able to down regulate the pathway of cytokines production either in HTLV-1 chronically infected MT-2 cell line or in human CD4+ cells infected in vitro with HTLV-1.
Fuggetta, M.p., Bordignon, V., Cottarelli, A., Macchi, B., Frezza, C., Cordiali-Fei, P., et al. (2016). Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 35(1), 118-126 [10.1186/s13046-016-0398-8].
Tipologia: | Articolo su rivista | |
Citazione: | Fuggetta, M.p., Bordignon, V., Cottarelli, A., Macchi, B., Frezza, C., Cordiali-Fei, P., et al. (2016). Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 35(1), 118-126 [10.1186/s13046-016-0398-8]. | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore BIO/14 | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/s13046-016-0398-8 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 2016 | |
Titolo: | Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol | |
Autori: | ||
Autori: | Fuggetta, Mp; Bordignon, V; Cottarelli, A; Macchi, B; Frezza, C; Cordiali-Fei, P; Ensoli, F; Ciafre, S; Marino-Merlo, F; Mastino, A; Ravagnan, G | |
Appare nelle tipologie: | 01 - Articolo su rivista |
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