The c-MYC oncoprotein is a DNA binding transcription factor that enhances the expression of many active genes. c-MYC transcriptional signatures vary according to the transcriptional program defined in each cell type during differentiation. Little is known on the involvement of c-MYC in regulation of gene expression programs that are induced by extracellular cues such as a changing microenvironment. Here we demonstrate that inhibition of c-MYC in glioblastoma multiforme cells blunts hypoxia-dependent glycolytic reprogramming and mitochondria fragmentation in hypoxia. This happens because c-MYC inhibition alters the cell transcriptional response to hypoxia and finely tunes the expression of a subset of Hypoxia Inducible Factor 1-regulated genes. We also show that genes whose expression in hypoxia is affected by c-MYC inhibition are able to distinguish the Proneural subtype of glioblastoma multiforme, thus potentially providing a molecular signature for this class of tumors that are the least tractable among glioblastomas.
Mongiardi, M.p., Savino, M., Falchetti, M., Illi, B., Bozzo, F., Valle, C., et al. (2016). c-MYC inhibition impairs hypoxia response in glioblastoma multiforme. ONCOTARGET, 7(22), 33257-33271 [10.18632/oncotarget.8921].
Tipologia: | Articolo su rivista | |
Citazione: | Mongiardi, M.p., Savino, M., Falchetti, M., Illi, B., Bozzo, F., Valle, C., et al. (2016). c-MYC inhibition impairs hypoxia response in glioblastoma multiforme. ONCOTARGET, 7(22), 33257-33271 [10.18632/oncotarget.8921]. | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore BIO/11 | |
Revisione (peer review): | Esperti anonimi | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.18632/oncotarget.8921 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 22-apr-2016 | |
Titolo: | c-MYC inhibition impairs hypoxia response in glioblastoma multiforme | |
Autori: | ||
Autori: | Mongiardi, Mp; Savino, M; Falchetti, M; Illi, B; Bozzo, F; Valle, C; HELMER CITTERICH, M; Ferre, F; Nasi, S; Levi, A | |
Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Mongiardi_etal_2016.pdf | N/A | Non specificato | UNIVERSITY_NETWORK Richiedi una copia |