CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishThe identification of new biomarkers and targets for tailored therapy in human colorectal cancer (CRC) onset and progression is an interesting challenge. CRC tissue produces an excess of ox-LDL, suggesting a close correlation between lipid dysfunction and malignant transformation. Lectin-like oxidized LDL receptor-1 (LOX-1) is involved in several mechanisms closely linked to tumorigenesis. Here we report a tumor specific LOX-1 overexpression in human colon cancers: LOX-1 results strongly increased in the 72% of carcinomas (P<0.001), and strongly overexpressed in 90% of highly aggressive and metastatic tumours (P<0.001), as compared to normal mucosa. Moreover LOX-1 results modulated since the early stage of the disease (adenomas vs normal mucosa; P<0.001) suggesting an involvement in tumor insurgence and progression. The in vitro knockdown of LOX-1 in DLD-1 and HCT-8 colon cancer cells by siRNA and anti-LOX-1 antibody triggers to an impaired proliferation rate and affects the maintenance of cell growth and tumorigenicity. The wound-healing assay reveals an evident impairment in closing the scratch. Lastly knockdown of LOX-1 delineates a specific pattern of volatile compounds characterized by the presence of a butyrate derivative, suggesting a potential role of LOX-1 in tumor-specific epigenetic regulation in neoplastic cells. The role of LOX-1 as a novel biomarker and molecular target represents a concrete opportunity to improve current therapeutic strategies for CRC. In addition, the innovative application of a technology focused to the identification of LOX-1 driven volatiles specific to colorectal cancer provides a promising diagnostic tool for CRC screening and for monitoring the response to therapy.
Murdocca, M., Mango, R., Pucci, S., Biocca, S., Testa, B., Capuano, R., et al. (2016). The lectin-like oxidized LDL receptor-1: A new potential molecular target in colorectal cancer. ONCOTARGET, 7(12), 14765-14780.
| Tipologia: | Articolo su rivista | |
| Citazione: | Murdocca, M., Mango, R., Pucci, S., Biocca, S., Testa, B., Capuano, R., et al. (2016). The lectin-like oxidized LDL receptor-1: A new potential molecular target in colorectal cancer. ONCOTARGET, 7(12), 14765-14780. | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.18632/oncotarget.7430 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2016 | |
| Titolo: | The lectin-like oxidized LDL receptor-1: A new potential molecular target in colorectal cancer | |
| Autori: | ||
| Autori: | Murdocca, M; Mango, R; Pucci, S; Biocca, S; Testa, B; Capuano, R; Paolesse, R; Sanchez, M; Orlandi, A; Di Natale, C; Novelli, G; Sangiuolo, FC | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 570cc85808ae31998899fe12.pdf | N/A |  | Open Access Visualizza/Apri |
Copyright © 2022