Fungal infections are a major complication in hematologic and neoplastic patients causing severe morbidity and mortality. Aspergillus fumigatus and Candida albicans are among the most invasive opportunistic pathogens in immunocompromised patients, and classic antifungal drugs are frequently unsuccessful in these patients. Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate monocyte-mediated immunity, but no consideration was given to its potential direct fungistatic activity. Moreover, ATRA offers the opportunity for systemic therapy.

Campione, E., Gaziano, R., Marino, D., & Orlandi, A. (2016). Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans. DRUG DESIGN, DEVELOPMENT AND THERAPY, 10, 1551-1555 [10.2147/DDDT.S93985].

Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

CAMPIONE, ELENA;GAZIANO, ROBERTA;ORLANDI, AUGUSTO
2016

Abstract

Fungal infections are a major complication in hematologic and neoplastic patients causing severe morbidity and mortality. Aspergillus fumigatus and Candida albicans are among the most invasive opportunistic pathogens in immunocompromised patients, and classic antifungal drugs are frequently unsuccessful in these patients. Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate monocyte-mediated immunity, but no consideration was given to its potential direct fungistatic activity. Moreover, ATRA offers the opportunity for systemic therapy.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - Anatomia Patologica
Settore MED/35 - Malattie Cutanee e Veneree
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
all-trans retinoic acid; fungal infections; fungistatic activity
Campione, E., Gaziano, R., Marino, D., & Orlandi, A. (2016). Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans. DRUG DESIGN, DEVELOPMENT AND THERAPY, 10, 1551-1555 [10.2147/DDDT.S93985].
Campione, E; Gaziano, R; Marino, D; Orlandi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/159865
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