Due to its crucial role in pathophysiology, erythrocyte deformability represents a subject of intense experimental and modeling research. Here a computational approach to electro-deformation for erythrocyte mechanical characterization is presented. Strong points of the proposed strategy are: (1) an accurate computation of the mechanical actions induced on the cell by the electric field, (2) a microstructurally-based continuum model of the erythrocyte mechanical behavior, (3) an original rotationfree shell finite element, especially suited to the application in hand. As proved by the numerical results, the developed tool is effective and sound, and can foster the role of electro-deformation in single-cell mechanical phenotyping.

Nodargi, N.A., Bisegna, P., & Caselli, F. (2016). Effective computational modeling of erythrocyte electro-deformation. MECCANICA, 1-19 [10.1007/s11012-016-0424-0].

Effective computational modeling of erythrocyte electro-deformation

Nodargi, NA;BISEGNA, PAOLO;CASELLI, FEDERICA
2016-04-06

Abstract

Due to its crucial role in pathophysiology, erythrocyte deformability represents a subject of intense experimental and modeling research. Here a computational approach to electro-deformation for erythrocyte mechanical characterization is presented. Strong points of the proposed strategy are: (1) an accurate computation of the mechanical actions induced on the cell by the electric field, (2) a microstructurally-based continuum model of the erythrocyte mechanical behavior, (3) an original rotationfree shell finite element, especially suited to the application in hand. As proved by the numerical results, the developed tool is effective and sound, and can foster the role of electro-deformation in single-cell mechanical phenotyping.
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-IND/34 - Bioingegneria Industriale
English
Con Impact Factor ISI
Electro-deformation; Maxwell stress tensor; Erythrocyte mechanics; Homogenization; Finite elements; Corotational formulation
Accesso Aperto MIUR
Nodargi, N.A., Bisegna, P., & Caselli, F. (2016). Effective computational modeling of erythrocyte electro-deformation. MECCANICA, 1-19 [10.1007/s11012-016-0424-0].
Nodargi, N; Bisegna, P; Caselli, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/159598
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