Background: Since prehistoric times Southern Italy has been a cultural crossroads of the Mediterranean basin. Genetic data on the peoples of Basilicata and Calabria are scarce and, particularly, no records on mtDNA variability have been published. Aim: In this study mtDNA haplotypes of populations from Basilicata, Calabria and Sicily are compared with those of other Italian and Mediterranean populations, so as to investigate their genetic relationships. Subjects and methods: A total of 341 individuals was analysed for mtDNA in order to provide their classification into haplogroups. Multivariate analysis was used to compare the studied populations with other Mediterranean samples; median-joining network analysis was applied to observe the relationship between the major lineages of the Southern Italians. Results: The haplogroup distribution in the Southern Italian samples falls within the typical pattern of mtDNA variability of Western Eurasia. The comparison with other Mediterranean countries showed a substantial homogeneity of the area, which is probably related to the historic contact through the Mediterranean Sea. Conclusion: The mtDNA analysis demonstrated that Southern Italy displays a typical pattern of Mediterranean basin variability, even though it appears plausible that Southern Italy was less affected by the effects of the Late Glacial Maximum, which reduced genetic diversity in Europe.

Ottoni, C., MARTINEZ-LABARGA, M.c., Vitelli, L., Scano, G., Fabrini, E., Contini, I., et al. (2009). Human mitochondrial DNA variation in Southern Italy. ANNALS OF HUMAN BIOLOGY, 36, 785-811 [10.3109/03014460903198509].

Human mitochondrial DNA variation in Southern Italy

Ottoni, C;MARTINEZ-LABARGA, MARIA CRISTINA;SCANO, GIUSEPPINA;CONTINI, IRENE;RICKARDS, OLGA
2009-01-01

Abstract

Background: Since prehistoric times Southern Italy has been a cultural crossroads of the Mediterranean basin. Genetic data on the peoples of Basilicata and Calabria are scarce and, particularly, no records on mtDNA variability have been published. Aim: In this study mtDNA haplotypes of populations from Basilicata, Calabria and Sicily are compared with those of other Italian and Mediterranean populations, so as to investigate their genetic relationships. Subjects and methods: A total of 341 individuals was analysed for mtDNA in order to provide their classification into haplogroups. Multivariate analysis was used to compare the studied populations with other Mediterranean samples; median-joining network analysis was applied to observe the relationship between the major lineages of the Southern Italians. Results: The haplogroup distribution in the Southern Italian samples falls within the typical pattern of mtDNA variability of Western Eurasia. The comparison with other Mediterranean countries showed a substantial homogeneity of the area, which is probably related to the historic contact through the Mediterranean Sea. Conclusion: The mtDNA analysis demonstrated that Southern Italy displays a typical pattern of Mediterranean basin variability, even though it appears plausible that Southern Italy was less affected by the effects of the Late Glacial Maximum, which reduced genetic diversity in Europe.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/08
English
Con Impact Factor ISI
mtDNA; HVS-I; coding region; genetic diversity; haplogroups
http://dx.doi.org/10.3109/03014460903198509
Ottoni, C., MARTINEZ-LABARGA, M.c., Vitelli, L., Scano, G., Fabrini, E., Contini, I., et al. (2009). Human mitochondrial DNA variation in Southern Italy. ANNALS OF HUMAN BIOLOGY, 36, 785-811 [10.3109/03014460903198509].
Ottoni, C; MARTINEZ-LABARGA, Mc; Vitelli, L; Scano, G; Fabrini, E; Contini, I; Biondi, G; Rickards, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/15570
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