In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD14 expression. Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the release of soluble TNF-alpha and leads to a simultaneous increase of membrane TNF-alpha. These results show that MTB-induced apoptosis in macrophages is reduced by a MMP inhibitor and most probably is related to TNF-alpha release. This identifies BB-94 as a simultaneous anti-apoptotic and anti-inflammatory molecule during MTB infection.
Santucci, M.B., Ciaramella, A., Mattei, M., Sumerska, T., & Fraziano, M. (2003). Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY, 3(12), 1657-1665.
Tipologia: | Articolo su rivista |
Citazione: | Santucci, M.B., Ciaramella, A., Mattei, M., Sumerska, T., & Fraziano, M. (2003). Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY, 3(12), 1657-1665. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S1567-5769(03)00202-9 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | nov-2003 |
Titolo: | Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages |
Autori: | |
Autori: | Santucci, MB; Ciaramella, A; Mattei, M; Sumerska, T; Fraziano, M |
Appare nelle tipologie: | 01 - Articolo su rivista |