Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.

Spalletta, G., Cravello, L., Gianni, W., Piras, F., Iorio, M., Cacciari, C., et al. (2016). Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment. JOURNAL OF ALZHEIMER'S DISEASE, 50(3), 807-816 [10.3233/JAD-150484].

Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment

SANCESARIO, GIUSEPPE;CALTAGIRONE, CARLO;
2016

Abstract

Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
eng
Amnestic mild cognitive impairment; episodic memory; hippocampus; homotaurine; structural magnetic resonance imaging; tramiprosate
Spalletta, G., Cravello, L., Gianni, W., Piras, F., Iorio, M., Cacciari, C., et al. (2016). Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment. JOURNAL OF ALZHEIMER'S DISEASE, 50(3), 807-816 [10.3233/JAD-150484].
Spalletta, G; Cravello, L; Gianni, W; Piras, F; Iorio, M; Cacciari, C; Casini, A; Chiapponi, C; Sancesario, G; Fratangeli, C; Orfei, M; Caltagirone, C; Piras, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/153907
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