Bilateral posterior periventricular nodular heterotopia PNH is a complex malformation of cortical development with imaging features distinguishing it from classic bilateral PNH associated with filamin (FLNA) mutations. It distinctively consists of variably sized nodules of neurons along the trigones and temporal or occipital horns of the lateral ventricles and spectrum of developmental disorders of the mid-/hindbrain. This association suggests that pPNH is part of a more diffuse process of posterior or infrasylvian brain developmental abnormalities other than just a disorder of neuronal migration.
Guglielmi, V., Floris, R., D'Adamo, M., Garaci, F., Novelli, G., Sbraccia, P. (2016). Massive obesity and hyperphagia in posterior bilateral periventricular heterotopias: Case report. BMC MEDICAL GENETICS, 17(1), 18 [10.1186/s12881-016-0282-6].
Massive obesity and hyperphagia in posterior bilateral periventricular heterotopias: Case report
Guglielmi, V;FLORIS, ROBERTO;D'ADAMO, MONICA;GARACI, FRANCESCO;NOVELLI, GIUSEPPE;SBRACCIA, PAOLO
2016-01-01
Abstract
Bilateral posterior periventricular nodular heterotopia PNH is a complex malformation of cortical development with imaging features distinguishing it from classic bilateral PNH associated with filamin (FLNA) mutations. It distinctively consists of variably sized nodules of neurons along the trigones and temporal or occipital horns of the lateral ventricles and spectrum of developmental disorders of the mid-/hindbrain. This association suggests that pPNH is part of a more diffuse process of posterior or infrasylvian brain developmental abnormalities other than just a disorder of neuronal migration.| File | Dimensione | Formato | |
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