Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome.

Pardini, M., Elia, M., Garaci, F., Guida, S., Coniglione, F., Krueger, F., et al. (2012). Long-term cognitive and behavioral therapies, combined with augmentative communication, are related to uncinate fasciculus integrity in autism. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 42(4), 585-592 [10.1007/s10803-011-1281-2].

Long-term cognitive and behavioral therapies, combined with augmentative communication, are related to uncinate fasciculus integrity in autism

GARACI, FRANCESCO;CONIGLIONE, FILADELFO;EMBERTI, LEONARDO
2012-04

Abstract

Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
Settore MED/37 - Neuroradiologia
Settore MED/42 - Igiene Generale e Applicata
Settore MED/36 - Diagnostica per Immagini e Radioterapia
eng
Con Impact Factor ISI
Nerve Fibers, Myelinated; Young Adult; Humans; Communication; Brain; Retrospective Studies; Nerve Net; Diffusion Magnetic Resonance Imaging; Autistic Disorder; Behavior Therapy; Neural Pathways; Adolescent; Male
Pardini, M., Elia, M., Garaci, F., Guida, S., Coniglione, F., Krueger, F., et al. (2012). Long-term cognitive and behavioral therapies, combined with augmentative communication, are related to uncinate fasciculus integrity in autism. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 42(4), 585-592 [10.1007/s10803-011-1281-2].
Pardini, M; Elia, M; Garaci, F; Guida, S; Coniglione, F; Krueger, F; Benassi, F; Emberti, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/15101
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