Context: Subjects with normal glucose tolerance (NGT) but 1-h postload glucose ≥ 155 mg/dL (NGT-1h-high) exhibit an intermediate cardiometabolic risk profile between individuals with NGT and impaired glucose tolerance (IGT). Objective: This study aimed to evaluate whether NGT-1h-high subjects have different cardiometabolic characteristics and an increased risk of type 2 diabetes compared with individuals with isolated impaired fasting glucose (IFG). Setting, Design, and Patients: A cross-sectional analysis was performed on 595 nondiabetic subjects who underwent an oral glucose tolerance test and an euglycemic hyperinsulinemic clamp in an ambulatory care setting. In addition, a longitudinal analysis was performed on 392 individuals, who were reexamined after a followup of 5.2 ± 0.9 y. Main Outcome Measures: Insulin sensitivity, beta-cell function, and risk of developing diabetes were measured. Results: Subjects with NGT-1h-high have a significant reduction of peripheral insulin sensitivity and beta-cell function, assessed by the disposition index, compared with either 1-h postload glucose < 155 mg/dL (NGT-1h-low) or IFG individuals, but not compared with IGT. Among the 392 subjects studied in the longitudinal analysis the incidence rate of type 2 diabetes over the follow-up period was 2.9, 16.7, 12.5, and 31.4% for subjects with NGT-1h-low, NGT-1h-high, IFG, and IGT, respectively. In a Cox proportional hazard regression analysis the risk of developing diabetes for NGT-1h-high subjects was 4.02 (95% confidence interval [CI] 1.06–15.26); an even higher risk (6.67; 95% CI, 2.09–21.24) was observed in subjects with IGT, but not in the isolated IFG group (1.91; 95% CI, 0.44–8.29). Conclusions: NGT-1h-high subjects exhibit a higher risk of developing diabetes than those with IFG or NGT-1h-low, likely due to decreased insulin sensitivity and beta-cell function.
Fiorentino, T., Marini, M., Andreozzi, F., Arturi, F., Succurro, E., Perticone, M., et al. (2015). One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 100(10), 3744-3751.
|Tipologia:||Articolo su rivista|
|Citazione:||Fiorentino, T., Marini, M., Andreozzi, F., Arturi, F., Succurro, E., Perticone, M., et al. (2015). One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 100(10), 3744-3751.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1210/jc.2015-2573|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2015|
|Titolo:||One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose|
|Autori:||Fiorentino, T; Marini, M; Andreozzi, F; Arturi, F; Succurro, E; Perticone, M; Sciacqua, A; Hribal, M; Perticone, F; Sesti, G|
|Appare nelle tipologie:||01 - Articolo su rivista|