Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important cause of acute food- borne zoonoses worldwide, typically carried by pigs. It is well known that Salmonella has evolved a wide array of strategies enabling it to invade the host, but little information is available on the specific host responses to Salmonella infections. In the present study, we used an in vivo approach (involving piglets infected with a virulent or an attenuated S. Typhimurium strain) coupled to histological and proteomic analysis of the cecum mucosa, to highlight the host pathways activated during S. Typhimurium infection. We confirm the complex host-pathogen interaction. Our data showed that the metabolic and the cytoskeleton organization functions were the most significantly altered. In particular, the modifications of energy metabolic pathway could suggest a "nutriprive" mechanism, in which the host reduce its metabolic and energetic status to limit Salmonella infection. This study could represent a preliminary approach, providing information useful to better understand the host-Salmonella interaction.

Miarelli, M., Drumo, R., Signorelli, F., Marchitelli, C., Pavone, S., Pesciaroli, M., et al. (2016). Salmonella Typhimurium infection primes a nutriprive mechanism in piglets. VETERINARY MICROBIOLOGY, 186, 117-125 [10.1016/j.vetmic.2016.02.006].

Salmonella Typhimurium infection primes a nutriprive mechanism in piglets

Ammendola S;Battistoni A;
2016

Abstract

Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important cause of acute food- borne zoonoses worldwide, typically carried by pigs. It is well known that Salmonella has evolved a wide array of strategies enabling it to invade the host, but little information is available on the specific host responses to Salmonella infections. In the present study, we used an in vivo approach (involving piglets infected with a virulent or an attenuated S. Typhimurium strain) coupled to histological and proteomic analysis of the cecum mucosa, to highlight the host pathways activated during S. Typhimurium infection. We confirm the complex host-pathogen interaction. Our data showed that the metabolic and the cytoskeleton organization functions were the most significantly altered. In particular, the modifications of energy metabolic pathway could suggest a "nutriprive" mechanism, in which the host reduce its metabolic and energetic status to limit Salmonella infection. This study could represent a preliminary approach, providing information useful to better understand the host-Salmonella interaction.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Attenuated strain; Histological analysis; Piglets; Proteoma; Salmonella Typhimurium; Virulent strain
Miarelli, M., Drumo, R., Signorelli, F., Marchitelli, C., Pavone, S., Pesciaroli, M., et al. (2016). Salmonella Typhimurium infection primes a nutriprive mechanism in piglets. VETERINARY MICROBIOLOGY, 186, 117-125 [10.1016/j.vetmic.2016.02.006].
Miarelli, M; Drumo, R; Signorelli, F; Marchitelli, C; Pavone, S; Pesciaroli, M; Ruggieri, J; Chirullo, B; Ammendola, S; Battistoni, A; Alborali, G; Manuali, E; Pasquali, P
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Miarelli et al.pdf

non disponibili

Descrizione: articolo prncipale
Licenza: Non specificato
Dimensione 2.32 MB
Formato Adobe PDF
2.32 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/150547
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact