Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
Reggiani, A., Barbaccia, M.L., Spano, P.F., & Trabucchi, M. (1980). Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas. PSYCHOPHARMACOLOGY, 67(3), 261-264.
Tipologia: | Articolo su rivista |
Citazione: | Reggiani, A., Barbaccia, M.L., Spano, P.F., & Trabucchi, M. (1980). Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas. PSYCHOPHARMACOLOGY, 67(3), 261-264. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/14 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1980 |
Titolo: | Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas |
Autori: | |
Autori: | Reggiani, A; Barbaccia, ML; Spano, PF; Trabucchi, M |
Appare nelle tipologie: | 01 - Articolo su rivista |