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EnglishIn rats, a selective inhibition for 3 weeks of monoamineoxydase (MAO) type B elicited by daily doses of pargyline (2.5 mumol/kg) or (-)-deprenyl (1 mumol/kg) attenuated the NE dependent stimulation of cortical adenylate cyclase and reduced the number of brain recognition sites for beta-adrenergic receptor ligands. Similar actions were not elicited by a comparable dose regimen of (+)-amphetamine. Hence the inhibition of MAO B mimicks responses that are typically elicited by antidepressants. The molecular nature of the mechanisms involved cannot be understood, however, these mechanisms may not be identical for pargyline and (-)-deprenyl because this drug but not pargyline increased the number of [3H]imipramine recognition sites. Even high daily doses of pargyline (100 mumol/kg, for 3 weeks) failed to change [3H]imipramine binding though they still down regulated beta-adrenergic recognition sites, the NE stimulation of adenylate cyclase and the Bmax of [3H]mianserin and [3H]spiroperidol binding.
Zsilla, G., Barbaccia, M.L., Gandolfi, O., Knoll, J., & Costa, E. (1983). (-)-Deprenyl a selective MAO "B' inhibitor, increases [3H]imipramine binding and decreases beta-adrenergic receptor function. EUROPEAN JOURNAL OF PHARMACOLOGY, 89(1-2), 111-117.
| Tipologia: | Articolo su rivista | |
| Citazione: | Zsilla, G., Barbaccia, M.L., Gandolfi, O., Knoll, J., & Costa, E. (1983). (-)-Deprenyl a selective MAO "B' inhibitor, increases [3H]imipramine binding and decreases beta-adrenergic receptor function. EUROPEAN JOURNAL OF PHARMACOLOGY, 89(1-2), 111-117. | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/14 | |
| Revisione (peer review): | Sì, ma tipo non specificato | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 22-apr-1983 | |
| Titolo: | (-)-Deprenyl a selective MAO "B' inhibitor, increases [3H]imipramine binding and decreases beta-adrenergic receptor function | |
| Autori: | ||
| Autori: | Zsilla, G; Barbaccia, ML; Gandolfi, O; Knoll, J; Costa, E | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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