The effects of the Y2 receptor agonist neuropeptide Y NPY-(13-36) on the depolarization-evoked release of [3H]noradrenaline (NA) from synaptosomal preparations of the medulla oblongata, the hypothalamus, the hippocampal formation and the parieto-occipital cortex of the male rat were studied. NPY-(13-36) (0.1-100 nM) caused a concentration-related inhibition of the depolarization-induced release of [3H]NA in all areas studied, except the parieto-occipital cortex. The results indicate that NPY Y2 receptors are present on NA terminals in all areas studied, except the parieto-occipital cortex and inhibit depolarization-evoked [3H]NA release.

Martire, M., Pistritto, G., Mores, N., Agnati, L.F., & Fuxe, K. (1993). Region-specific inhibition of potassium-evoked [3H]noradrenaline release from rat brain synaptosomes by neuropeptide Y-(13-36). Involvement of NPY receptors of the Y2 type. EUROPEAN JOURNAL OF PHARMACOLOGY, 230(2), 231-234.

Region-specific inhibition of potassium-evoked [3H]noradrenaline release from rat brain synaptosomes by neuropeptide Y-(13-36). Involvement of NPY receptors of the Y2 type

PISTRITTO, GIUSEPPA;
1993-01-12

Abstract

The effects of the Y2 receptor agonist neuropeptide Y NPY-(13-36) on the depolarization-evoked release of [3H]noradrenaline (NA) from synaptosomal preparations of the medulla oblongata, the hypothalamus, the hippocampal formation and the parieto-occipital cortex of the male rat were studied. NPY-(13-36) (0.1-100 nM) caused a concentration-related inhibition of the depolarization-induced release of [3H]NA in all areas studied, except the parieto-occipital cortex. The results indicate that NPY Y2 receptors are present on NA terminals in all areas studied, except the parieto-occipital cortex and inhibit depolarization-evoked [3H]NA release.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Phentolamine; Male; Synaptosomes; Potassium; Peptide Fragments; Rats, Wistar; Rats; Norepinephrine; Receptors, Neuropeptide Y; Brain; Animals; Neuropeptide Y
Martire, M., Pistritto, G., Mores, N., Agnati, L.F., & Fuxe, K. (1993). Region-specific inhibition of potassium-evoked [3H]noradrenaline release from rat brain synaptosomes by neuropeptide Y-(13-36). Involvement of NPY receptors of the Y2 type. EUROPEAN JOURNAL OF PHARMACOLOGY, 230(2), 231-234.
Martire, M; Pistritto, G; Mores, N; Agnati, L; Fuxe, K
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/14978
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