The aim of this study was to investigate the mechanisms through which bacterial lipopolysaccharide (LPS) stimulates prostaglandin (PG) production in rat hypothalamic astroglial cells in vitro. The latter were treated with LPS alone or LPS plus antagonists of the interleukin-1 (IL-1) and nitric oxide (NO) pathways, and the subsequent changes in cyclooxygenase (COX) activity were monitored by measuring a COX end-product, prostaglandin E2 (PGE2), released into the incubation medium. LPS produced a concentration-dependent increase in PGE2 release from astroglia after 24 h incubation; experiments with selective antagonists showed that the increase in PGE2 release induced by LPS may be, at least in part, mediated by IL-1 and NO.
Pistritto, G., Ciabattoni, G., Mancuso, C., Tringali, G., Preziosi, P., & Navarra, P. (2000). Signaling pathways involved in lipopolysaccharide stimulation of prostaglandin production by rat hypothalamic astroglial cells. JOURNAL OF ENDOTOXIN RESEARCH, 6(4), 307-311.
Tipologia: | Articolo su rivista |
Citazione: | Pistritto, G., Ciabattoni, G., Mancuso, C., Tringali, G., Preziosi, P., & Navarra, P. (2000). Signaling pathways involved in lipopolysaccharide stimulation of prostaglandin production by rat hypothalamic astroglial cells. JOURNAL OF ENDOTOXIN RESEARCH, 6(4), 307-311. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/14 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2000 |
Titolo: | Signaling pathways involved in lipopolysaccharide stimulation of prostaglandin production by rat hypothalamic astroglial cells |
Autori: | |
Autori: | Pistritto, G; Ciabattoni, G; Mancuso, C; Tringali, G; Preziosi, P; Navarra, P |
Appare nelle tipologie: | 01 - Articolo su rivista |