A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.

Manzari, V., Gismondi, A., Barillari, G., Morrone, S., Modesti, A., ALBONICI BOVE, L., et al. (1987). HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia. SCIENCE, 238(4833), 1581-3.

HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia

MANZARI, VITTORIO;BARILLARI, GIOVANNI;MODESTI, ANDREA;ALBONICI BOVE, LOREDANA;
1987-12-11

Abstract

A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.
11-dic-1987
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Male; Leukemia; Deltaretrovirus; Lymphoma; Microscopy, Electron; Female; Antigens, Viral; T-Lymphocytes; Humans
Manzari, V., Gismondi, A., Barillari, G., Morrone, S., Modesti, A., ALBONICI BOVE, L., et al. (1987). HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia. SCIENCE, 238(4833), 1581-3.
Manzari, V; Gismondi, A; Barillari, G; Morrone, S; Modesti, A; ALBONICI BOVE, L; De Marchis, L; Fazio, V; Gradilone, A; Zani, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14907
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