A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.
Manzari, V., Gismondi, A., Barillari, G., Morrone, S., Modesti, A., Albonici, L., et al. (1987). HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia. SCIENCE, 238(4833), 1581-3.
|Tipologia:||Articolo su rivista|
|Citazione:||Manzari, V., Gismondi, A., Barillari, G., Morrone, S., Modesti, A., Albonici, L., et al. (1987). HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia. SCIENCE, 238(4833), 1581-3.|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||11-dic-1987|
|Titolo:||HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia|
|Autori:||Manzari, V; Gismondi, A; Barillari, G; Morrone, S; Modesti, A; Albonici, L; De Marchis, L; Fazio, V; Gradilone, A; Zani, M|
|Appare nelle tipologie:||01 - Articolo su rivista|