A large number of PROSITE patterns select false positives and/or miss known true positives. It is possible that--at least in some cases--the weak specificity and/or sensitivity of a pattern is due to the fact that one, or maybe more, functional and/or structural key residues are not represented in the pattern. Multiple sequence alignments are commonly used to build functional sequence patterns. If residues structurally conserved in proteins sharing a function cannot be aligned in a multiple sequence alignment, they are likely to be missed in a standard pattern construction procedure.

Via, A., HELMER CITTERICH, M. (2004). A structural study for the optimisation of functional motifs encoded in protein sequences. BMC BIOINFORMATICS, 5, 50 [10.1186/1471-2105-5-50].

A structural study for the optimisation of functional motifs encoded in protein sequences

HELMER CITTERICH, MANUELA
2004-04-30

Abstract

A large number of PROSITE patterns select false positives and/or miss known true positives. It is possible that--at least in some cases--the weak specificity and/or sensitivity of a pattern is due to the fact that one, or maybe more, functional and/or structural key residues are not represented in the pattern. Multiple sequence alignments are commonly used to build functional sequence patterns. If residues structurally conserved in proteins sharing a function cannot be aligned in a multiple sequence alignment, they are likely to be missed in a standard pattern construction procedure.
30-apr-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11 - BIOLOGIA MOLECOLARE
English
Con Impact Factor ISI
Sensitivity and Specificity; Computational Biology; Conserved Sequence; Amino Acid Motifs; Proteins; Databases, Protein; Amino Acid Sequence; False Negative Reactions
http://www.biomedcentral.com/1471-2105/5/50
Via, A., HELMER CITTERICH, M. (2004). A structural study for the optimisation of functional motifs encoded in protein sequences. BMC BIOINFORMATICS, 5, 50 [10.1186/1471-2105-5-50].
Via, A; HELMER CITTERICH, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14892
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