Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.
Silvestri, I., ALBONICI BOVE, L., Ciotti, M., Lombardi, M., SINIBALDI SALIMEI, P., Manzari, V., et al. (1995). Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells. EXPERIENTIA, 51(11), 1076-80.
Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells
ALBONICI BOVE, LOREDANA;SINIBALDI SALIMEI, PAOLA;MANZARI, VITTORIO;
1995-11-15
Abstract
Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
