Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.

Silvestri, I., ALBONICI BOVE, L., Ciotti, M., Lombardi, M., SINIBALDI SALIMEI, P., Manzari, V., et al. (1995). Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells. EXPERIENTIA, 51(11), 1076-80.

Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells

ALBONICI BOVE, LOREDANA;SINIBALDI SALIMEI, PAOLA;MANZARI, VITTORIO;
1995-11-15

Abstract

Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.
15-nov-1995
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Protein Biosynthesis; Hydroxybenzoic Acids; Antiviral Agents; RNA, Viral; Cell Line; RNA; Dose-Response Relationship, Drug; Virus Replication; T-Lymphocytes; Ribitol; Humans; Blotting, Northern; RNA-Directed DNA Polymerase; Antineoplastic Agents; DNA Replication; Human T-lymphotropic virus 1; Cell Division
Silvestri, I., ALBONICI BOVE, L., Ciotti, M., Lombardi, M., SINIBALDI SALIMEI, P., Manzari, V., et al. (1995). Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells. EXPERIENTIA, 51(11), 1076-80.
Silvestri, I; ALBONICI BOVE, L; Ciotti, M; Lombardi, M; SINIBALDI SALIMEI, P; Manzari, V; Orlando, P; Carretta, F; Strazzullo, G; Grippo, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14847
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