Acute foot shock stress elicits a selective and time-dependent increase of neuroactive steroid (pregnenolone, progesterone, allotetrahydrodeoxycorticosterone) concentrations in rat brain cortex, accompanied by a marked increase of plasma corticosterone. The brain cortical neuroactive steroid levels peaked between 10 and 30 min poststress and returned to control values by 2 h. Abecarnil (0.3 mg/kg), i.p.), a beta-carboline derivative with anxiolytic properties, completely antagonized the effect of foot shock on brain cortical neuroactive steroids. A single administration of the anxiogenic beta-carboline FG 7142 (15 mg/kg, i.p.), in contrast, mimicked the effect of foot shock. These data support the hypothesis for the existence of a functional relationship between brain neuroactive steroid concentrations and GABAA receptor function/emotional state of the animal.

Barbaccia, M.L., Roscetti, G., Bolacchi, F., Concas, A., Mostallino, M.C., Purdy, R.H., et al. (1996). Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 54(1), 205-210.

Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil

BARBACCIA, MARIA LUISA;ROSCETTI, GIANNA;
1996-05

Abstract

Acute foot shock stress elicits a selective and time-dependent increase of neuroactive steroid (pregnenolone, progesterone, allotetrahydrodeoxycorticosterone) concentrations in rat brain cortex, accompanied by a marked increase of plasma corticosterone. The brain cortical neuroactive steroid levels peaked between 10 and 30 min poststress and returned to control values by 2 h. Abecarnil (0.3 mg/kg), i.p.), a beta-carboline derivative with anxiolytic properties, completely antagonized the effect of foot shock on brain cortical neuroactive steroids. A single administration of the anxiogenic beta-carboline FG 7142 (15 mg/kg, i.p.), in contrast, mimicked the effect of foot shock. These data support the hypothesis for the existence of a functional relationship between brain neuroactive steroid concentrations and GABAA receptor function/emotional state of the animal.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Male; Time Factors; Carbolines; Electroshock; Rats; Animals; Anti-Anxiety Agents; Rats, Sprague-Dawley; Steroids; Brain Chemistry; Carbon Dioxide; Stress, Psychological; Receptors, GABA-A; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid
Barbaccia, M.L., Roscetti, G., Bolacchi, F., Concas, A., Mostallino, M.C., Purdy, R.H., et al. (1996). Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 54(1), 205-210.
Barbaccia, Ml; Roscetti, G; Bolacchi, F; Concas, A; Mostallino, M; Purdy, R; Biggio, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/14844
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