Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.

Barbaccia, M.L., Roscetti, G., Trabucchi, M., Ambrosio, C., & Massotti, M. (1992). Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces. EUROPEAN JOURNAL OF PHARMACOLOGY, 219(3), 485-486.

Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces

BARBACCIA, MARIA LUISA;ROSCETTI, GIANNA;TRABUCCHI, MARCO MARIO;
1992-09-04

Abstract

Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
eng
Con Impact Factor ISI
Male; Desoxycorticosterone; Progesterone; Forskolin; Cyclic AMP; Rats; Pregnenolone; Animals; Rats, Sprague-Dawley; Cerebral Cortex
Barbaccia, M.L., Roscetti, G., Trabucchi, M., Ambrosio, C., & Massotti, M. (1992). Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces. EUROPEAN JOURNAL OF PHARMACOLOGY, 219(3), 485-486.
Barbaccia, Ml; Roscetti, G; Trabucchi, Mm; Ambrosio, C; Massotti, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/14838
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