Diazepam-binding-inhibitor (DBI) and gamma-aminobutyric acid (GABA) are colocalized in neurons in the brain. This system has been implicated in anxiety and in the regulation of corticotropin-releasing hormone (CRH) secretion. Alcohol has direct and indirect effects on the functioning of GABAA receptors. Abstinent alcoholics are, on the average, more anxious than controls. In tests of animal behavior, DBI has anxiogenic, and alcohol has anxiolytic potency. Therefore, we compared alcoholic patients and healthy controls for cerebrospinal fluid (CSF) levels of DBI, and looked for a correlation between CSF levels of DBI and CRH. There was no significant difference in CSF concentrations of DBI between the two groups and no significant correlation between CSF DBI and our measure of anxiety. However, there was a significant positive correlation between CSF levels of DBI and CRH in both the alcoholic and control groups.

Roy, A., Dejong, J., Adinoff, B., Barbaccia, M.l., Costa, E., Guidotti, A., et al. (1990). CSF diazepam-binding inhibitor in alcoholics and normal controls. PSYCHIATRY RESEARCH, 31(3), 261-266.

CSF diazepam-binding inhibitor in alcoholics and normal controls

BARBACCIA, MARIA LUISA;
1990-03-01

Abstract

Diazepam-binding-inhibitor (DBI) and gamma-aminobutyric acid (GABA) are colocalized in neurons in the brain. This system has been implicated in anxiety and in the regulation of corticotropin-releasing hormone (CRH) secretion. Alcohol has direct and indirect effects on the functioning of GABAA receptors. Abstinent alcoholics are, on the average, more anxious than controls. In tests of animal behavior, DBI has anxiogenic, and alcohol has anxiolytic potency. Therefore, we compared alcoholic patients and healthy controls for cerebrospinal fluid (CSF) levels of DBI, and looked for a correlation between CSF levels of DBI and CRH. There was no significant difference in CSF concentrations of DBI between the two groups and no significant correlation between CSF DBI and our measure of anxiety. However, there was a significant positive correlation between CSF levels of DBI and CRH in both the alcoholic and control groups.
mar-1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Diazepam Binding Inhibitor; Male; Middle Aged; Sex Factors; Female; Alcoholism; Neuropeptides; Corticotropin-Releasing Hormone; Adult; Humans
Roy, A., Dejong, J., Adinoff, B., Barbaccia, M.l., Costa, E., Guidotti, A., et al. (1990). CSF diazepam-binding inhibitor in alcoholics and normal controls. PSYCHIATRY RESEARCH, 31(3), 261-266.
Roy, A; Dejong, J; Adinoff, B; Barbaccia, Ml; Costa, E; Guidotti, A; Linnoila, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14837
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