Despite the emergence of several new effective treatments for metastatic castration-resistant prostate cancer patients, disease progression inevitably occurs, leading scientific community to carefully look for novel therapeutic targets of prostate cancer. Kallikrein (KLK)-related peptidases have been demonstrated to facilitate prostate tumorigenesis and disease progression through the development of an oncogenic microenvironment for prostate cells.

Cereda, V., Formica, V., Menghi, A., Pellicori, S., Roselli, M. (2015). Kallikrein-related peptidases targeted therapies in prostate cancer: Perspectives and challenges. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 24(7), 929-947 [10.1517/13543784.2015.1035708].

Kallikrein-related peptidases targeted therapies in prostate cancer: Perspectives and challenges

CEREDA, VITTORE;Formica, V;ROSELLI, MARIO
2015-01-01

Abstract

Despite the emergence of several new effective treatments for metastatic castration-resistant prostate cancer patients, disease progression inevitably occurs, leading scientific community to carefully look for novel therapeutic targets of prostate cancer. Kallikrein (KLK)-related peptidases have been demonstrated to facilitate prostate tumorigenesis and disease progression through the development of an oncogenic microenvironment for prostate cells.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - ONCOLOGIA MEDICA
English
engineered inhibitors; immunotherapy; kallikrein; kallikrein-activated prodrugs; kallikrein-targeted therapy; prostate cancer; Animals; Antineoplastic Agents; Humans; Kallikreins; Male; Prostatic Neoplasms
Cereda, V., Formica, V., Menghi, A., Pellicori, S., Roselli, M. (2015). Kallikrein-related peptidases targeted therapies in prostate cancer: Perspectives and challenges. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 24(7), 929-947 [10.1517/13543784.2015.1035708].
Cereda, V; Formica, V; Menghi, A; Pellicori, S; Roselli, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/147628
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