Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus, hypertension and atherosclerosis. The aim of this study was to investigate the effects of TIMP3 on cardiac energy homeostasis during increased metabolic stress conditions.
Stohr, R., Kappel, B., Carnevale, D., Cavalera, M., Mavilio, M., Arisi, I., et al. (2015). TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. MOLECULAR METABOLISM, 4(10), 741-752 [10.1016/j.molmet.2015.07.007].
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice
CAVALERA, MICHELEMembro del Collaboration Group
;Casagrande, V;RIZZA, STEFANOMembro del Collaboration Group
;MAURIELLO, ALESSANDROMembro del Collaboration Group
;MENGHINI, ROSSELLAMembro del Collaboration Group
;FEDERICI, MASSIMO
Funding Acquisition
2015-01-01
Abstract
Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus, hypertension and atherosclerosis. The aim of this study was to investigate the effects of TIMP3 on cardiac energy homeostasis during increased metabolic stress conditions.| File | Dimensione | Formato | |
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