Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus, hypertension and atherosclerosis. The aim of this study was to investigate the effects of TIMP3 on cardiac energy homeostasis during increased metabolic stress conditions.

Stohr, R., Kappel, B., Carnevale, D., Cavalera, M., Mavilio, M., Arisi, I., et al. (2015). TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. MOLECULAR METABOLISM, 4(10), 741-752 [10.1016/j.molmet.2015.07.007].

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

CAVALERA, MICHELE
Membro del Collaboration Group
;
RIZZA, STEFANO
Membro del Collaboration Group
;
MAURIELLO, ALESSANDRO
Membro del Collaboration Group
;
MENGHINI, ROSSELLA
Membro del Collaboration Group
;
FEDERICI, MASSIMO
Funding Acquisition
2015

Abstract

Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus, hypertension and atherosclerosis. The aim of this study was to investigate the effects of TIMP3 on cardiac energy homeostasis during increased metabolic stress conditions.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/09 - Medicina Interna
Settore MED/08
English
Con Impact Factor ISI
Apelin; Arrhythmia; Heart; Lipid metabolism; Oxidative stress; TIMP3
Stohr, R., Kappel, B., Carnevale, D., Cavalera, M., Mavilio, M., Arisi, I., et al. (2015). TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice. MOLECULAR METABOLISM, 4(10), 741-752 [10.1016/j.molmet.2015.07.007].
Stohr, R; Kappel, B; Carnevale, D; Cavalera, M; Mavilio, M; Arisi, I; Fardella, V; Cifelli, G; Casagrande, V; Rizza, S; Cattaneo, A; Mauriello, A; Menghini, R; Lembo, G; Federici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/146067
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