Cartilage undergoes drastic structural changes during the development of osteoarthritis and cannot heal itself due to a defective chondrocyte response. Thus, much effort has been invested in the development of disease modifying drugs able to block key mediators within the cartilage matrix and biochemical pathways inside chondrocytes. However, the delivery of therapeutic agents into cartilage is ineffective. This has led to the use of cartilage-targeted nanodrugs to accumulate therapeutic agents into specific cartilage sub-compartments. This review will describe the nanodrugs targeted to specific components of cartilage matrix to generate drug reservoirs within the cartilage. The nanodrugs used as chondrocyte-specific gene delivery systems are also described. Although the use of cartilage-targeted nanodrugs in osteoarthritis is still in its infancy, these studies lay the foundation for the development of novel approaches for preventing the progression of cartilage breakdown and improving the quality of life of patients with osteoarthritis.

Bottini, M., Bhattacharya, K., Fadeel, B., Magrini, A., Bottini, N., Rosato, N. (2015). Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. NANOMEDICINE, 12(2), 255-268 [10.1016/j.nano.2015.09.013].

Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy

MAGRINI, ANDREA;BOTTINI, NUNZIO;ROSATO, NICOLA
2015

Abstract

Cartilage undergoes drastic structural changes during the development of osteoarthritis and cannot heal itself due to a defective chondrocyte response. Thus, much effort has been invested in the development of disease modifying drugs able to block key mediators within the cartilage matrix and biochemical pathways inside chondrocytes. However, the delivery of therapeutic agents into cartilage is ineffective. This has led to the use of cartilage-targeted nanodrugs to accumulate therapeutic agents into specific cartilage sub-compartments. This review will describe the nanodrugs targeted to specific components of cartilage matrix to generate drug reservoirs within the cartilage. The nanodrugs used as chondrocyte-specific gene delivery systems are also described. Although the use of cartilage-targeted nanodrugs in osteoarthritis is still in its infancy, these studies lay the foundation for the development of novel approaches for preventing the progression of cartilage breakdown and improving the quality of life of patients with osteoarthritis.
In corso di stampa
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/44 - Medicina del Lavoro
English
Biological identity; Cartilage; Nanodrugs; Osteoarthritis; Targeting agents; Therapeutic index
Bottini, M., Bhattacharya, K., Fadeel, B., Magrini, A., Bottini, N., Rosato, N. (2015). Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. NANOMEDICINE, 12(2), 255-268 [10.1016/j.nano.2015.09.013].
Bottini, M; Bhattacharya, K; Fadeel, B; Magrini, A; Bottini, N; Rosato, N
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
PMID 26707894 - Nanomedicine.pdf

non disponibili

Licenza: Copyright dell'editore
Dimensione 1.13 MB
Formato Adobe PDF
1.13 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/142187
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 35
social impact