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EnglishIntroduction: Adalimumab is effective in inducing and maintaining response/remission in patients with Crohn’s Disease (CD) either naive to biological therapies or following secondary failure of infliximab. Aim: To present the first ‘real-life’ survey data from England and Ireland on the use of adalimumab. Method: A retrospective audit conducted by a web-based questionnaire in England/Ireland. Results: We analysed data on 61 patients (35 female) with a median age of 33 years (range 17-71) with average follow-up of 8 months. Maximal maintenance dose was 40mg every other week in 84% of patients, 40mg weekly in 13% and 80mg weekly in 3%. Maintenance adalimumab achieved remission in 57% of patients. The ongoing response rate was 83.6%. An additional 8% had a secondary loss of response after average of 8.4 months (range 2-17). 23% had adverse effects, of which local pain 29%, infection 36%, headaches 14%, leucopenia (on AZA) 7%, a painful rash 7%, serum-sickness type reaction 7%. Adverse events led to discontinuation in 2 patients. Conclusion: This English/Irish audit show acceptable response/remission and safety profile of adalimumab in the treatment of CD. In contrast to previous data from Scotland, dose escalation was only seen in 16% of patients. The majority of responders were steroid-free at follow-up.
Iacucci, M. (2010). Survey regarding the use of adalimumab as maintenance therapy in Crohn’s disease in England and Ireland.
| Autori: | |
| Titolo: | Survey regarding the use of adalimumab as maintenance therapy in Crohn’s disease in England and Ireland |
| Data di pubblicazione: | 9-ago-2010 |
| Anno Accademico: | A.A. 2009/2010 |
| Settore Scientifico Disciplinare: | Settore MED/12 - Gastroenterologia |
| Lingua: | en |
| Tipologia: | Tesi di dottorato |
| Citazione: | Iacucci, M. (2010). Survey regarding the use of adalimumab as maintenance therapy in Crohn’s disease in England and Ireland. |
| Appare nelle tipologie: | 07 - Tesi di dottorato |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| PhD thesis adalimumab in CD.pdf | N/A | Open Access Visualizza/Apri |
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