Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders, with rising incidence but little effective therapeutic intervention available. Currently two main clinical features are described to diagnose ASDs: impaired social interaction and communication, and repetitive behaviors. Much work has focused on understanding underlying causes of ASD by generating animal models of the disease, in the hope of discovering signaling pathways and cellular targets for drug intervention. Here we review how ASD behavioral phenotypes can be modeled in the mouse, the most common animal model currently in use in this field, and discuss examples of genetic mouse models of ASD with behavioral features that recapitulate various symptoms of ASD.

Pasciuto, E., Borrie, S., Kanellopoulos, A., Santos, A., Cappuyns, E., D'Andrea, L., et al. (2015). Autism Spectrum Disorders: Translating human deficits into mouse behavior. NEUROBIOLOGY OF LEARNING AND MEMORY, 124, 71-87 [10.1016/j.nlm.2015.07.013].

Autism Spectrum Disorders: Translating human deficits into mouse behavior

BAGNI, CLAUDIA
Conceptualization
2015-01-01

Abstract

Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders, with rising incidence but little effective therapeutic intervention available. Currently two main clinical features are described to diagnose ASDs: impaired social interaction and communication, and repetitive behaviors. Much work has focused on understanding underlying causes of ASD by generating animal models of the disease, in the hope of discovering signaling pathways and cellular targets for drug intervention. Here we review how ASD behavioral phenotypes can be modeled in the mouse, the most common animal model currently in use in this field, and discuss examples of genetic mouse models of ASD with behavioral features that recapitulate various symptoms of ASD.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/13 - BIOLOGIA APPLICATA
English
Autism Spectrum Disorders; Cognitive impairment; Human behavior; Hyperactivity; Mouse behavior; Repetitive behaviors; Social interaction
Pasciuto, E., Borrie, S., Kanellopoulos, A., Santos, A., Cappuyns, E., D'Andrea, L., et al. (2015). Autism Spectrum Disorders: Translating human deficits into mouse behavior. NEUROBIOLOGY OF LEARNING AND MEMORY, 124, 71-87 [10.1016/j.nlm.2015.07.013].
Pasciuto, E; Borrie, S; Kanellopoulos, A; Santos, A; Cappuyns, E; D'Andrea, L; Pacini, L; Bagni, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/140916
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