Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Osteoporosis is a widespread disorder affecting millions of individuals of all ethnic backgrounds worldwide, particularly among older women. It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in the risk of fracture. Sarcopenia is considered to be one of the major factors responsible for functional limitations and motor dependency in elderly persons. In age-related muscle atrophy, a decrease in muscle fiber size and number, and a preferential loss of type II fibers have been reported. A decrease in the circulating levels of specific hormones (e.g., estrogen, testosterone, growth hormone, and insulin-like growth factor-1) has been shown to be associated with sarcopenia and this appears to play an important role in its pathogenesis.

Tarantino, U., Baldi, J., Celi, M., Rao, C., Liuni, F., Iundusi, R., et al. (2013). Osteoporosis and sarcopenia: The connections. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 25(1 SUPPL.), 93-95 [10.1007/s40520-013-0097-7].

Osteoporosis and sarcopenia: The connections

TARANTINO, UMBERTO;IUNDUSI, RICCARDO;GASBARRA, ELENA
2013

Abstract

Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Osteoporosis is a widespread disorder affecting millions of individuals of all ethnic backgrounds worldwide, particularly among older women. It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in the risk of fracture. Sarcopenia is considered to be one of the major factors responsible for functional limitations and motor dependency in elderly persons. In age-related muscle atrophy, a decrease in muscle fiber size and number, and a preferential loss of type II fibers have been reported. A decrease in the circulating levels of specific hormones (e.g., estrogen, testosterone, growth hormone, and insulin-like growth factor-1) has been shown to be associated with sarcopenia and this appears to play an important role in its pathogenesis.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/33 - Malattie Apparato Locomotore
English
Aged; Aged, 80 and over; Aging; Bone and Bones; Estrogens; Female; Frail Elderly; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Middle Aged; Muscle, Skeletal; Muscles; Muscular Atrophy; Osteoblasts; Osteoporosis; Quality of Life; Sarcopenia; Testosterone
Tarantino, U., Baldi, J., Celi, M., Rao, C., Liuni, F., Iundusi, R., et al. (2013). Osteoporosis and sarcopenia: The connections. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 25(1 SUPPL.), 93-95 [10.1007/s40520-013-0097-7].
Tarantino, U; Baldi, J; Celi, M; Rao, C; Liuni, F; Iundusi, R; Gasbarra, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/140901
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