Aims: Nevirapine is widely used to treat HIV-1 infection to prevent mother-to-child transmission; unfortunately adverse drug reactions have been reported. Our aim was to identify genes/variants involved in nevirapine-induced hepatotoxicity.

Ciccacci, C., Borgiani, P., Ceffa, S., Sirianni, E., Marazzi, M., DORO ALTAN, A.m., et al. (2010). Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. PHARMACOGENOMICS, 11(1), 23-31 [10.2217/pgs.09.142].

Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique

BORGIANI, PAOLA;DORO ALTAN, ANNA MARIA;NOVELLI, GIUSEPPE;PALOMBI, LEONARDO
2010-01-01

Abstract

Aims: Nevirapine is widely used to treat HIV-1 infection to prevent mother-to-child transmission; unfortunately adverse drug reactions have been reported. Our aim was to identify genes/variants involved in nevirapine-induced hepatotoxicity.
gen-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/42 - IGIENE GENERALE E APPLICATA
Settore MED/03 - GENETICA MEDICA
English
Con Impact Factor ISI
Nevirapine; Male; Retrospective Studies; Mozambique; Alleles; Cytochrome P-450 CYP3A; Genetic Association Studies; HIV Infections; Female; Polymorphism, Single Nucleotide; Anti-HIV Agents; Genotype; Drug-Induced Liver Injury; P-Glycoprotein; Humans; Infectious Disease Transmission, Vertical; Odds Ratio; Aryl Hydrocarbon Hydroxylases; Pregnancy; Haplotypes; Oxidoreductases, N-Demethylating; Case-Control Studies
Ciccacci, C., Borgiani, P., Ceffa, S., Sirianni, E., Marazzi, M., DORO ALTAN, A.m., et al. (2010). Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. PHARMACOGENOMICS, 11(1), 23-31 [10.2217/pgs.09.142].
Ciccacci, C; Borgiani, P; Ceffa, S; Sirianni, E; Marazzi, M; DORO ALTAN, Am; Paturzo, G; Bramanti, P; Novelli, G; Palombi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/14078
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