Oxford classification of Immunoglobulin A Nephropathy (IgAN) identifies four pathological features as predictors of renal outcome (MEST-score): mesangial proliferation (M); endocapillary proliferation (E); segmental glomerulosclerosis (S); tubular atrophy/interstitial fibrosis (T). In particular extracapillary proliferation (Ex) was not considered as an independent histological variable predicting renal outcome. Recently the VALIGA study provided a validation of the Oxford classification in a large European cohort of IgAN patients and re-stated that Ex is not associated with a worse renal prognosis. We propose a retrospective study to evaluate the predictive value of the MEST-score in a multi-centre, single region group of patients from central Italy and in addition, to investigate Ex as a marker predicting renal outcome.

Serriello, I., Polci, R., Feriozzi, S., Gigante, A., Di Giulio, S., Rosa, M., et al. (2015). Extracapillary proliferation is an independent predictive factor in Immunoglobulin A nephropathy. NEPHROLOGY, 20(9), 654-659 [10.1111/nep.12497].

Extracapillary proliferation is an independent predictive factor in Immunoglobulin A nephropathy

MOROSETTI, MASSIMO;
2015

Abstract

Oxford classification of Immunoglobulin A Nephropathy (IgAN) identifies four pathological features as predictors of renal outcome (MEST-score): mesangial proliferation (M); endocapillary proliferation (E); segmental glomerulosclerosis (S); tubular atrophy/interstitial fibrosis (T). In particular extracapillary proliferation (Ex) was not considered as an independent histological variable predicting renal outcome. Recently the VALIGA study provided a validation of the Oxford classification in a large European cohort of IgAN patients and re-stated that Ex is not associated with a worse renal prognosis. We propose a retrospective study to evaluate the predictive value of the MEST-score in a multi-centre, single region group of patients from central Italy and in addition, to investigate Ex as a marker predicting renal outcome.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/14 - Nefrologia
English
Immunoglobulin A nephropathy; end-stage kidney disease; glomerulonephritis; immunopathology; renal biopsy
Serriello, I., Polci, R., Feriozzi, S., Gigante, A., Di Giulio, S., Rosa, M., et al. (2015). Extracapillary proliferation is an independent predictive factor in Immunoglobulin A nephropathy. NEPHROLOGY, 20(9), 654-659 [10.1111/nep.12497].
Serriello, I; Polci, R; Feriozzi, S; Gigante, A; Di Giulio, S; Rosa, M; Galliani, M; Morosetti, M; Pugliese, F; Petitti, T; Onetti Muda, A; Giannakakis, K
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/140556
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