Background: Squamous cell carcinoma of the penis (SCCP) is the most common penis neoplasia, favoured by phimosis, HPV infection and scleroatrophic lichen. The classic therapy is surgical with anatomic demolition, which often causes important psychological problems. Other non-demolitive therapies can be utilized, such as radiotherapy, brachytherapy and topical medical treatment. Objectives: we propose a new non-invasive therapy called "Dermo beta brachytherapy (DBBT) with 188-Re" in which a synthetic inert resin-matrix containing a radioactive beta-emitting isotope is applied on the surface of the tumor lesion. Materials and methods: a total of 15 patients with a histologically confirmed diagnosis of SCCP were enrolled for treatment (DBBT). Results: of the 15 patients, 12 healed, 1 was lost at follow-up and 2 did not respond to therapy. Conclusion: The results indicate that DBBT is an effective treatment for SCC of the penis, sparing the anatomical integrity of the organ, and allowing normal sexual activity.

Carrozzo, A.m., Sedda, A., Muscardin, L., Donati, P., & Cipriani, C. (2013). Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: A new therapy. EUROPEAN JOURNAL OF DERMATOLOGY, 23(2), 183-188 [10.1684/ejd.2013.1927].

Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: A new therapy

CARROZZO, ANNA MARIA;
2013

Abstract

Background: Squamous cell carcinoma of the penis (SCCP) is the most common penis neoplasia, favoured by phimosis, HPV infection and scleroatrophic lichen. The classic therapy is surgical with anatomic demolition, which often causes important psychological problems. Other non-demolitive therapies can be utilized, such as radiotherapy, brachytherapy and topical medical treatment. Objectives: we propose a new non-invasive therapy called "Dermo beta brachytherapy (DBBT) with 188-Re" in which a synthetic inert resin-matrix containing a radioactive beta-emitting isotope is applied on the surface of the tumor lesion. Materials and methods: a total of 15 patients with a histologically confirmed diagnosis of SCCP were enrolled for treatment (DBBT). Results: of the 15 patients, 12 healed, 1 was lost at follow-up and 2 did not respond to therapy. Conclusion: The results indicate that DBBT is an effective treatment for SCC of the penis, sparing the anatomical integrity of the organ, and allowing normal sexual activity.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/35 - Malattie Cutanee e Veneree
English
Brachytherapy; Dermobeta- brachytherapy; Squamous cell carcinoma of penis; Surface mould brachytherapy; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Penile Neoplasms; Radioisotopes; Rhenium; Brachytherapy; 2708
http://www.jle.com/e-docs/00/04/85/DE/vers_alt/VersionPDF.pdf
Carrozzo, A.m., Sedda, A., Muscardin, L., Donati, P., & Cipriani, C. (2013). Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: A new therapy. EUROPEAN JOURNAL OF DERMATOLOGY, 23(2), 183-188 [10.1684/ejd.2013.1927].
Carrozzo, Am; Sedda, A; Muscardin, L; Donati, P; Cipriani, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/140044
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