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EnglishSome of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-α and IFN-β receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking Tlr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D.p., Adam, J., et al. (2014). Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. NATURE MEDICINE, 20(11), 1301-1309 [10.1038/nm.3708].
| Tipologia: | Articolo su rivista | |
| Citazione: | Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D.p., Adam, J., et al. (2014). Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. NATURE MEDICINE, 20(11), 1301-1309 [10.1038/nm.3708]. | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/09 | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/nm.3708 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2014 | |
| Titolo: | Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy | |
| Autori: | ||
| Autori: | Sistigu, A; Yamazaki, T; Vacchelli, E; Chaba, K; Enot, Dp; Adam, J; Vitale, I; Goubar, A; Baracco, Ee; Remedios, C; Fend, L; Hannani, D; Aymeric, L; Ma, Y; Niso-Santano, M; Kepp, O; Schultze, Jl; Tuting, T; Belardelli, F; Bracci, L; La Sorsa, V; Ziccheddu, G; Sestili, P; Urbani, F; Delorenzi, M; Lacroix-Triki, M; Quidville, V; Conforti, R; Spano, J-; Pusztai, L; Poirier-Colame, V; Delaloge, S; Penault-Llorca, F; Ladoire, S; Arnould, L; Cyrta, J; Dessoliers, M-; Eggermont, A; Bianchi, Me; Pittet, M; Engblom, C; Pfirschke, C; Preville, X; Uze, G; Schreiber, Rd; Chow, Mt; Smyth, Mj; Proietti, E; Andre, F; Kroemer, G; Zitvogel, L | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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