Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.

DI SANO, F., Piacentini, M. (2012). Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2012, 651805-651805 [10.1155/2012/651805].

Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases

DI SANO, FEDERICA;PIACENTINI, MAURO
2012-05-01

Abstract

Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.
mag-2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
DI SANO, F., Piacentini, M. (2012). Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases. INTERNATIONAL JOURNAL OF CELL BIOLOGY, 2012, 651805-651805 [10.1155/2012/651805].
DI SANO, F; Piacentini, M
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
int j cell biol.pdf

accesso aperto

Licenza: Non specificato
Dimensione 784 kB
Formato Adobe PDF
784 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/139036
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? ND
social impact