Proton caged compounds exhibit a characteristic behavior when directly dosed into cells or being coupled to gold nanoparticles prior to the dosing.When irradiated in the near ultraviolet region, they release protons that interac twith intracellular HCO3- to yield H2CO3. The dissociation of carbonic acid,then, releases CO2 that can be distinctively singled out in infrared spectra. In the process of searching a pathway to augment the intra- cellular uptake of proton caged compounds,we probed the asso- ciation of 1-(2-nitrophenyl)-ethylhexadecylsulfonate (HDNS) with DMSO, an agent to enhance the membrane permeability.We found out a different UV-induced protonation mechanism that opens up to new conduits of employing of proton caged compounds.

Carbone, M., Sabbatella, G., Antonaroli, S., Remita, H., Orlando, V., Biagioni, M., et al. (2016). Exogenous control over intracellular acidification: Enhancement via proton caged compounds coupled to gold nanoparticles and an alternative pathway with DMSO. DATA IN BRIEF, 6, 745-749 [10.1016/j.dib.2015.12.032].

Exogenous control over intracellular acidification: Enhancement via proton caged compounds coupled to gold nanoparticles and an alternative pathway with DMSO

CARBONE, MARILENA;ANTONAROLI, SIMONETTA;
2016

Abstract

Proton caged compounds exhibit a characteristic behavior when directly dosed into cells or being coupled to gold nanoparticles prior to the dosing.When irradiated in the near ultraviolet region, they release protons that interac twith intracellular HCO3- to yield H2CO3. The dissociation of carbonic acid,then, releases CO2 that can be distinctively singled out in infrared spectra. In the process of searching a pathway to augment the intra- cellular uptake of proton caged compounds,we probed the asso- ciation of 1-(2-nitrophenyl)-ethylhexadecylsulfonate (HDNS) with DMSO, an agent to enhance the membrane permeability.We found out a different UV-induced protonation mechanism that opens up to new conduits of employing of proton caged compounds.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/03 - Chimica Generale e Inorganica
English
Con Impact Factor ISI
DMSO; Intracellular proton release; Proton caged compounds;
Proton caged compounds DMSO Intracellular protonrelease
http://www.sciencedirect.com/science/article/pii/S2352340915003984
Carbone, M., Sabbatella, G., Antonaroli, S., Remita, H., Orlando, V., Biagioni, M., et al. (2016). Exogenous control over intracellular acidification: Enhancement via proton caged compounds coupled to gold nanoparticles and an alternative pathway with DMSO. DATA IN BRIEF, 6, 745-749 [10.1016/j.dib.2015.12.032].
Carbone, M; Sabbatella, G; Antonaroli, S; Remita, H; Orlando, V; Biagioni, M; Nucara, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/137721
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