Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials? © The Royal Society of Chemistry 2015.

Walkey, C., Das, S., Seal, S., Erlichman, J., Heckman, K., Ghibelli, L., et al. (2015). Catalytic properties and biomedical applications of cerium oxide nanoparticles. ENVIRONMENTAL SCIENCE. NANO, 2(1), 33-53 [10.1039/c4en00138a].

Catalytic properties and biomedical applications of cerium oxide nanoparticles

GHIBELLI, LINA;TRAVERSA, ENRICO;
2015-01-01

Abstract

Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials? © The Royal Society of Chemistry 2015.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-IND/22 - SCIENZA E TECNOLOGIA DEI MATERIALI
English
http://www.scopus.com/inward/record.url?eid=2-s2.0-84922495759&partnerID=40&md5=b77fb5c84bc981476db09eeca2248a5a
Walkey, C., Das, S., Seal, S., Erlichman, J., Heckman, K., Ghibelli, L., et al. (2015). Catalytic properties and biomedical applications of cerium oxide nanoparticles. ENVIRONMENTAL SCIENCE. NANO, 2(1), 33-53 [10.1039/c4en00138a].
Walkey, C; Das, S; Seal, S; Erlichman, J; Heckman, K; Ghibelli, L; Traversa, E; Mcginnis, J; Self, W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/136184
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